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Active Pharmaceutical Ingredients (APIs)
  • Atorvastatin Calcium Trihydrate

    • API Product   :   

      Atorvastatin Calcium Trihydrate

    • CEP   :   


    • WCC   :   


    • Therapeutic Use    :   

      Lipid-regulating/anti-atheroma preparations

    • Originator   :   

      European Pharmacopoeia

    • CAS No.    :   


    • Trade Name.   :   

      Lipitor, Atorva

    • Molecular Weight   :   

      558.64 g/ mol

    • Molecular Formula   :   



    Atorvastatin is used along with a proper diet to help lower "bad" cholesterol and fats (such as LDL, triglycerides) and raise "good" cholesterol (HDL) in the blood. It belongs to a group of drugs known as "statins."

    General Description

    Atorvastatin undergoes rapid absorption when taken orally, with an approximate time to maximum plasma concentration (Tmax) of 1–2 h. The absolute bioavailability of the medication is about 14%, but the systemic availability for HMG-CoA reductase activity is approximately 30%. Atorvastatin undergoes high intestinal clearance and first-pass metabolism, which is the main cause for the low systemic availability. Administration of atorvastatin with food produces a 25% reduction in Cmax (rate of absorption) and a 9% reduction in AUC (extent of absorption), although food does not affect the plasma LDL-C-lowering efficacy of atorvastatin. Evening dose administration is known to reduce the Cmax and AUC by 30% each. However, time of administration does not affect the plasma LDL-C-lowering efficacy of atorvastatin.

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