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Active Pharmaceutical Ingredients (APIs)
  • Loperamide HCI

    • API Product   :   

      Loperamide HCI

    • CEP   :   


    • WCC   :   


    • Therapeutic Use    :   

      Antidiarrhoeals, oral electrolyte replacers and intestinal anti-inflammatories; Analgesics; All Other Therapeutic Products

    • Originator   :   

      Dainippon Pharmaceutical; Janssen L.P.

    • CAS No.    :   


    • Trade Name.   :   


    • Molecular Weight   :   

      477.037 g/mol (513.506 with HCl)

    • Molecular Formula   :   



    This medication is used to treat sudden diarrhea (including traveler's diarrhea). It works by slowing down the movement of the gut. This decreases the number of bowel movements and makes the stool less watery. Loperamide is also used to reduce the amount of discharge in patients who have had an ileostomy.

    General Description

    Loperamide, sold under the brand name Imodium, among others,[1] is a medication used to decrease the frequency of diarrhea.[2] It is often used for this purpose in gastroenteritis, inflammatory bowel disease, and short bowel syndrome.[2] It is not recommended for those with blood in the stool.[2] The medication is taken by mouth.[2]Common side effects include abdominal pain, constipation, sleepiness, vomiting, and a dry mouth.[2] It may increase the risk of toxic megacolon.[2] Loperamide's safety in pregnancy is unclear, but no evidence of harm has been found.[3] It appears to be safe in breastfeeding.[4] It is an opioid with no significant absorption from the gut and does not cross the blood–brain barrier when used at normal doses.[5] It works by slowing the contractions of the intestines.

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