Product Name   :    Ezetimibe 4.0% + Atorvastatin 4.0% DC Granules
Dosage Form   :    Ezetimibe 4.0% + Atorvastatin 4.0% DC Granules
Dose   :    10/10mg
Reference Product   :    Liptruzet
API : DMF; Dossier — CTD   :    Available
Originator   :    Schering-Plough
Hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitors (statins) are widely used as therapeutic drugs. Statins competitively inhibit HMG-CoA reductase, a rate-controlling enzyme of cholesterol synthesis. Statins also promote the synthesis of LDL receptors and lower LDL cholesterol levels in serum.
Ezetimibe is a drug that lowers plasma cholesterol levels. It acts by decreasing cholesterol absorption in the small intestine. It may be used alone (marketed as Zetia or Ezetrol), when other cholesterol-lowering medications are not tolerated, or together with statins (e.g., ezetimibe/simvastatin, marketed as Vytorin or Inegy) when statins alone do not control cholesterol.