Active Pharmaceutical Ingredients (APIs)

  • Aprepitant

    • API Product   :   

      Aprepitant

    • CEP   :   

      -

    • WCC   :   

      ?

    • Therapeutic Use    :   

      Antiemetics and antinauseants; Psychoanaleptics Excluding Anti-Obesity Preparations

    • Originator   :   

      Merck Sharp & Dohme

    • CAS No.    :   

      170729-80-3

    • Trade Name.   :   

      Emend

    • Molecular Weight   :   

      534.43 g·mol?1

    • Molecular Formula   :   

      C23H21F7N4O3

    Application

    Aprepitant is used with other medications to help prevent nausea and vomiting caused by cancer drug treatment (chemotherapy). This medication is also used to prevent nausea and vomiting after surgery. Aprepitant works by blocking one of the body's natural substances (substance P/neurokinin 1) that causes vomiting .

    General Description

    Aprepitant (brand name: Emend (the brand name used in all English-speaking countries)) is an antiemetic chemical compound that belongs to a class of drugs called substance P antagonists (SPA). It mediates its effect by blocking the neurokinin 1 (NK1) receptor. Aprepitant is manufactured by Merck & Co. under the brand name Emend for prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV) and for prevention of postoperative nausea and vomiting. It was approved by the FDA in 2003.Aprepitant may also be useful in the treatment of cyclic vomiting syndrome and late-stage chemotherapy induced vomiting, but there are few studies to date.