Irinotecan HCI
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API Product :
Irinotecan HCI
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CEP :
-
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WCC :
?
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Therapeutic Use :
Antineoplastics
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Originator :
Jon.Nelson
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CAS No. :
97682-44-5
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Trade Name. :
CAMPTOSAR
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Molecular Weight :
586.678 g/mol
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Molecular Formula :
C33H38N4O6
Application
Irinotecan. Irinotecan, sold under the brand name Camptosar among others, is a medication used to treat colon cancer, and small cell lung cancer. For colon cancer it is used either alone or with fluorouracil. For small cell lung cancer it is used with cisplatin.
General Description
Irinotecan, sold under the brand name Camptosar among others, is a medication used to treat colon cancer, and small cell lung cancer.[1] For colon cancer it is used either alone or with fluorouracil.[1] For small cell lung cancer it is used with cisplatin.[1] It is given by slow injection into a vein.[1] Common side effects include diarrhea, vomiting, bone marrow suppression, hair loss, shortness of breath, and fever.[1] Other severe side effects include blood clots, colon inflammation, and allergic reactions.[1] Those with two copies of the UGT1A1*28 gene variant are at higher risk for side effects.[1] Use during pregnancy can result in harm to the baby.[1] Irinotecan is in topoisomerase inhibitor family of medication.[2] It works by blocking topoisomerase 1 which results in DNA damage and cell death.