Ambrisentan*
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API Product :
Ambrisentan*
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CEP :
-
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WCC :
?
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Therapeutic Use :
Other cardiovascular products; Antihypertensives
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Originator :
Abbott GmbH & Co.
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CAS No. :
177036-94-1
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Trade Name. :
Letairis
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Molecular Weight :
378.421 g/mol
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Molecular Formula :
C22H22N2O4
Application
Ambrisentan is used to treat high blood pressure in the lungs (pulmonary arterial hypertension). This condition is thought to be caused by increased levels of a certain natural substance (endothelin-1). This medication blocks the effects of endothelin-1, thereby helping to decrease the blood pressure in the lungs, slow the worsening of symptoms, and improve your ability to exercise.
General Description
Ambrisentan (U.S. trade name Letairis; E.U. trade name Volibris; India trade name Pulmonext by MSN labs) is a drug indicated for use in the treatment of pulmonary hypertension. The peptide endothelin constricts muscles in blood vessels, increasing blood pressure. Ambrisentan, which relaxes those muscles, is an endothelin receptor antagonist, and is selective for the type A endothelin receptor (ETA).[1] Ambrisentan significantly improved exercise capacity (6-minute walk distance) compared with placebo in two double-blind, multicenter trials (ARIES-1 and ARIES-2).