API Product   :    Sacubitril-Valsartan*
CEP   :    -
WCC   :    -
Therapeutic Use    :    Urologicals; Other cardiovascular products
Urologicals; Other cardiovascular products
Originator   :    Novartis
CAS No.    :    936623-90-4
Trade Name.   :    Entresto, Azmarda
Molecular Weight   :    1916.018 g/mol
Molecular Formula   :    C96H120N12Na6O21
Valsartan is an angiotensin II receptor blocker (sometimes called an ARB). Valsartan keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow. Sacubitril and valsartan is a combination medicine used in certain people with chronic heart failure.
Sacubitril/valsartan, sold under the brand name Entresto among others, is a combination drug for use in heart failure developed by Novartis. It consists of the neprilysin inhibitor sacubitril and the angiotensin receptor blocker valsartan, in a 1:1 mixture by molecule count. It is recommended for use as a replacement for an ACE inhibitor or an angiotensin receptor blocker in people with heart failure with reduced ejection fraction. Potential side effects include angioedema, kidney problems, and low blood pressure. The risk of kidney problems and increased levels of serum potassium with sacubitril/valsartan is lower than that of an ACE inhibitor or angiotensin receptor blocker. The combination is sometimes described as an "angiotensin receptor-neprilysin inhibitor".