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Active Pharmaceutical Ingredients (APIs)
  • Sacubitril-Valsartan*

    • API Product   :   


    • CEP   :   


    • WCC   :   


    • Therapeutic Use    :   

      Urologicals; Other cardiovascular products

    • Originator   :   


    • CAS No.    :   


    • Trade Name.   :   

      Entresto, Azmarda

    • Molecular Weight   :   

      1916.018 g/mol

    • Molecular Formula   :   



    Valsartan is an angiotensin II receptor blocker (sometimes called an ARB). Valsartan keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow. Sacubitril and valsartan is a combination medicine used in certain people with chronic heart failure.

    General Description

    Sacubitril/valsartan, sold under the brand name Entresto among others, is a combination drug for use in heart failure developed by Novartis. It consists of the neprilysin inhibitor sacubitril and the angiotensin receptor blocker valsartan, in a 1:1 mixture by molecule count. It is recommended for use as a replacement for an ACE inhibitor or an angiotensin receptor blocker in people with heart failure with reduced ejection fraction.[1] Potential side effects include angioedema, kidney problems, and low blood pressure.[1] The risk of kidney problems and increased levels of serum potassium with sacubitril/valsartan is lower than that of an ACE inhibitor or angiotensin receptor blocker. The combination is sometimes described as an "angiotensin receptor-neprilysin inhibitor".

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