Granulation in Medicine

More than 90% of all therapeutic compounds are administered via the oral route, for which the tablet dosage form is by far the most popular. The quality of these solid oral dosage forms is governed by the physicochemical properties of the powders/granulations used in their formulation. Although direct compression of APIs (active pharmaceutical ingredients) and […]

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Granulation Techniques and Technologies

Granulation, a technique of particle enlargement by agglomeration, is one of the most significant unit operations in the production of pharmaceutical dosage forms, mostly tablets and capsules. During the granulation process, small fine or coarse particles are converted into large agglomerates called granules. Generally, granulation commences after initial dry mixing of the necessary powder ingredients […]

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Functionality of directly compressible adjuvants in the formulation of tablets

Over the past century, tablet manufacturers have developed materials and processes that can produce compressed tablets containing a precise amount of an active pharmaceutical ingredient (API) at high speed and at relatively low cost. The development in the field of APIs, excipients and tableting machines during thepast decades has made tablet manufacturing a science and the tablets […]

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Tableting by Direct Compression

Direct compression (DC) is by far the simplest means of production of a pharmaceutical tablet. It requires that only the active ingredient is properly blended with appropriate excipients before compression. Apart from the simplicity of formulation and manufacture, the key advantages of direct compression include: Reduced capital, labour and energy costs for manufacture Avoidance of […]

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